Several neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), are thought to be driven by the ‘seeded’ aggregation of cytoplasmic proteins such as tau and α-synuclein. This is a process that shares similarities with viral and prion infection: a seed of highly structured aggregated protein promotes the conversion of native protein to the aggregated state. Our group is dedicated to understanding how such protein conformations propagate and developing new methods for therapeutically targeting propagation. We draw on findings from the fields of virology, immunology, structural biology and cell biology to inform this approach.
We are situated in the Department of Clinical Neurosciences at the University of Cambridge, UK.