2023
Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells
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2022
Tau seeds from patients induce progressive supranuclear palsy pathology and symptoms in primates.
Darricau M, Katsinelos T, Raschella F, Milekovic T, Crochemore L, Li Q, Courtine G, McEwan WA, Dehay B, Bezard E, Planche V
Brain. 2022 Nov doi:10.1093/brain/awac428
Type-I Interferons in Alzheimer’s Disease and Other Tauopathies
Sanford SAI & McEwan WA
Front Cell Neurosci 2022 July doi: 10.3389/fncel.2022.949340
Cholesterol determines the cytosolic entry and seeded aggregation of tau.
Cell Rep. 2022 May 3;39(5):110776. doi: 10.1016/j.celrep.2022.110776.
Antibodies in the intracellular domain. (Editorial)
Semin Cell Dev Biol. 2022 Jun;126:97-98. doi: 10.1016/j.semcdb.2022.02.020. Epub 2022 Feb 28.
Targeted protein degradation using intracellular antibodies and its application to neurodegenerative disease.
Semin Cell Dev Biol. 2022 Jun;126:138-149. doi: 10.1016/j.semcdb.2021.09.012.
2021
Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates.
Brelstaff JH, Mason M, Katsinelos T, McEwan WA, Ghetti B, Tolkovsky AM, Spillantini MG.
Sci Adv. 2021 Oct doi: 10.1126/sciadv.abg4980.
Identification of cis-acting determinants mediating the unconventional secretion of tau
Katsinelos T, McEwan WA, Jahn TR, Nickel W.
Scientific Reports 2021 Jun 11:12946
Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.
Miller LVC, Mukadam AS, Durrant CS, Vaysburd MJ, Katsinelos T, Tuck BJ, Sanford S, Sheppard O, Knox C, Cheng S, James LC, Coleman MP, McEwan WA.
Acta Neuropathol Commun. 2021 Mar 12;9(1):41. doi: 10.1186/s40478-021-01141-6.
Target-induced clustering activates Trim-Away of pathogens and proteins
Zeng J, Santos AF, Mukadam AS, Osswald M, Jacques DA, Dickson CF, McLaughlin SH, Johnson CM, Kiss L, Luptak J, Renner N, Vaysburd M, McEwan WA, Morais-de-Sá E, Clift D, James LC.
Nat Struct Mol Biol. 2021 Feb 25. doi: 10.1038/s41594-021-00560-2.
2020
Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases
Aman Y, Ryan B, Torsetnes SB, Knapskog AB, Watne LO, McEwan WA, Fang EF.
Int Rev Neurobiol. 2020;155:169-202. doi: 10.1016/bs.irn.2020.02.008.
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species
Nachman E, Wentink AS, Madiona K, Bousset L, Katsinelos T, Allinson K, Kampinga H, McEwan WA, Jahn TR, Melki R, Mogk A, Bukau B, Nussbaum-Krammer C
J Biol Chem 2020 May 28. doi: 10.1074/jbc.RA120.013478
2019
The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration
Katsinelos T, Tuck BJ, Mukadam AS, McEwan WA.
Frontiers in Immunology 2019 May 31. doi: 10.3389/fimmu.2019.01139
2018
Acute and rapid degradation of endogenous proteins by Trim-Away.
Clift D, So C, McEwan WA, James LC, Schuh M.
Nat Protoc. 2018 Sep 24. doi: 10.1038/s41596-018-0028-3.
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis
Mallery DL, Márquez CL, McEwan WA, Dickson C, Jacques DA, Anandapadamanaban M, Bichel K, Towers GJ, Saiardi A, Böcking T, James LC
eLife 2018 Jun 7 e35335
Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.
Kundel F, Hong L, Falcon B, McEwan WA, Michaels TCT, Meisl G, Esteras N, Abramov AY, Knowles TJP, Goedert M, Klenerman D.
ACS Chem Neurosci. 2018 Apr 8. doi: 10.1021/acschemneuro.8b00094.
Relevant papers before lab started in 2017
A Method for the Acute and Rapid Degradation of Endogenous Proteins
Clift D, McEwan WA, Labzin LI, Konieczny V, Mogessie B, James LC, Schuh M.
Cell 2017 Dec 171 1692-1706
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.
McEwan WA, Falcon B, Vaysburd M, Clift D, Oblak AL, Ghetti B, Goedert M, James LC.
Proc Natl Acad Sci U S A. 2017 Jan 114 574-579
Surveillance for Intracellular Antibody by Cytosolic Fc Receptor TRIM21.
McEwan WA.
Antibodies 2016 Nov 5 21-33
Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21
McEwan WA, Tam JCH, Watkinson RE, Bidgood SR, Mallery DL, James LC.
Nat Immunol 2013 Apr 14 327-36
Regulation of Virus Neutralization and the Persistent Fraction by TRIM21
McEwan WA, Hauler F, Williams CR, Bidgood SR, Mallery DL, Crowther RA, James LC.
J Virol 2012 Aug 86 8482-9
Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)
Mallery DL, McEwan WA, Bidgood SR, Towers GJ, Johnson CM, James LC.
Proc Natl Acad Sci U S A 2010 Nov 107 19985-90
Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat
McEwan WA, Schaller T, Ylinen LM, Hosie MJ, Towers GJ, Willett BJ.
J Virol 2009 Aug 83 8270-5.
McEwan Lab 