Publications

1) A Method for the Acute and Rapid Degradation of Endogenous Proteins
Clift D, McEwan WA, Labzin LI, Konieczny V, Mogessie B, James LC, Schuh M.
Cell 2017 Nov Published Online

2) Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation.
McEwan WA, Falcon B, Vaysburd M, Clift D, Oblak AL, Ghetti B, Goedert M, James LC.
Proc Natl Acad Sci U S A. 2017 Jan 114 574-579

3) Surveillance for Intracellular Antibody by Cytosolic Fc Receptor TRIM21.
McEwan WA.
Antibodies 2016 Nov 5 21-33

4) HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis.
Jacques DJ, McEwan WA, Hilditch L, Price AJ, Towers GJ, James LC
Nature 2016 Aug 536 349-353

5) TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus.
Watkinson RE, McEwan WA, Tam JC, Vaysburd M, James LC.
PLoS Path 2015 Oct 11 e1005253

6) TRIM21-Dependent Intracellular Antibody Neutralization of Virus Infection
McEwan WA, James LC. Prog in Mol Biol and Transl
Science 2015 Jan 129 167-87

7) Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly
Price AJ, Jacques DA, McEwan WA, Fletcher AJ, Essig S, Chin JW, Halambage UD, Aiken C, James LC.
PLoS Pathog 2014 Oct 10 e1004459

8) Intracellular sensing of complement C3 activates cell autonomous immunity
Tam JC, Bidgood SR, McEwan WA, James LC.
Science 2014 Sep 345 1256-70

9) Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells
Bidgood SR, Tam JC, McEwan WA, Mallery DL, James LC.
Proc Natl Acad Sci U S A 2014 Sep 111 13463-8

10) Intracellular antibody immunity
Watkinson RE, McEwan WA, James LC.
J Clin Immunol 2014 Jul 1:S30-4

11) Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21
McEwan WA, Tam JCH, Watkinson RE, Bidgood SR, Mallery DL, James LC.
Nat Immunol 2013 Apr 14 327-36

12) AAA ATPase VCP is Essential for TRIM21-mediated Virus Neutralization
Hauler F, Mallery DL, McEwan WA, Bidgood SR, James LC. Proc Natl Acad Sci U S A 2012 Nov 109 19733-8

13) Regulation of Virus Neutralization and the Persistent Fraction by TRIM21
McEwan WA, Hauler F, Williams CR, Bidgood SR, Mallery DL, Crowther RA, James LC.
J Virol 2012 Aug 86 8482-91

14) Diverse HIV viruses are targeted by a conformationally dynamic antiviral
Caines MEC, Bichel K, Price AJ, McEwan WA, Towers GJ, Willett BJ, Freund SMV, James LC.
Nat Struc Mol Biol 2012 Mar 19 411-6

15) Intracellular antibody-mediated immunity and the role of TRIM21
McEwan WA, Mallery DL, Rhodes DA, Trowsdale J, James LC.
Bioessays 2011 Nov 33 803-9

16) Restriction of the felid lentiviruses by a synthetic feline TRIM5-CypA fusion
Dietrich I, McEwan WA, Hosie MJ, Willett BJ.
Vet Immunol Immunopathol 2011 Oct 143 235-42

17) Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)
Mallery DL, McEwan WA, Bidgood SR, Towers GJ, Johnson CM, James LC.
Proc Natl Acad Sci U S A 2010 Nov 107 19985-90

18) Potent lentiviral restriction by a synthetic feline TRIM5 cyclophilin A fusion
Dietrich I, Macintyre A, McMonagle E, Price AJ, James LC, McEwan WA, Hosie MJ, Willett BJ.
J Virol 2010 Sep 84 8980-5

19) Truncation of TRIM5 in the Feliformia explains the absence of retroviral restriction in cells of the domestic cat
McEwan WA, Schaller T, Ylinen LM, Hosie MJ, Towers GJ, Willett BJ.
J Virol 2009 Aug 83 8270-5.

20) Genetically divergent strains of feline immunodeficiency virus from the domestic cat (Felis catus) and the African lion (Panthera leo) share usage of CD134 and CXCR4 as entry receptors
McEwan WA, McMonagle EL, Logan N, Serra RC, Kat P, Vandewoude S, Hosie MJ, Willett BJ.
J Virol 2008 Nov 82 10953-8.

21) The lingering effects of an artificial blind spot
Morgan MJ, McEwan W, Solomon J.
PLoS One 2007 Feb 2 e256.