Cytosolic Protein Targeting

The mammalian cell cytoplasm contains numerous antiviral detectors that sense viral components and elicit their rapid degradation. The McEwan Lab asks whether this activity could be repurposed for promoting the selective degradation of unwanted or toxic proteins. The ability to destroy such proteins could represent a powerful therapeutic approach in several settings. Our current research focusses on tau, a protein which becomes misfolded during the course of Alzheimer’s disease.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s